CURRENT RESEARCH PROJECTS

1.  Lau G, Walker R, Laird P, Lewis P, Kuthubutheen J, Schultz A. Identifying barriers and facilitators for the effective diagnosis and provision of primary health care for otitis media from the perspective of carers of Aboriginal children. J Paediatr Child Health. 2024 Jul 20.

2.  Mead C, Kuthubutheen J, van den Berg M, Petta A. Primary contact physiotherapy for patients with suggested vestibulopathy for an Australian ENT clinic: a retrospective cohort study. The Journal of Laryngology & Otology. 2024;138(S2):S42-S46. 

3.  Kuthubutheen, Jafri∗; Sharon, Jeffrey D.†,‡; Jung, Benson T.‡; Sepahdari, Ali R.‡; Ng, Jia Hui§; Erickson, Signe∥; Peris, Hugo‡; De Juan, Eugene‡; Limb, Charles J.†,‡. Early Experience with a Novel Treatment for Menière’s Disease: A Long Acting Dexamethasone Formulation for Precise Delivery to the Round Window Membrane. Otology & Neurotology 45(5):p 564-571, June 2024

4.  MacKay CI, Kuthubutheen J, Campbell AJ. An overview of risk factors, management and prevention of cochlear implant infections. Curr Opin Infect Dis. 2024 Mar 28

5.  Garcia-Matte RJ, O'Neil LM, Chase C, Leeming P, Clack R, Rodrigues S, Kuthubutheen J. Long-Term Cochlear Implant Sound Processor Usage in Children with Single-Sided Deafness. Otol Neurotol. 2024 Apr 1;45(4):392-397. doi: 10.1097/MAO.0000000000004156. PMID: 38478407.

6.  Altamimi AA, Brennan-Jones CG, Robinson M, Kuthubutheen J, Herbert H, Tran TT, Veselinović T, Edmunds M, Oremulé B, Alenezi EM, Richmond PC, Choi RS, Li I. A hospital-based asynchronous ENT telehealth service for children with otitis media: Cost-minimisation and improved access. J Telemed Telecare. 2024 Jan 31:1357633X231223994. doi: 

10.1177/1357633X231223994. Epub ahead of print. PMID: 38295365.

7.  Quick ME, Brennan-Jones CG, Kuthubutheen J. Remote paediatric ear examination comparing video-otoscopy and still otoscopy clinician rated outcomes. Int J Pediatr Otorhinolaryngol. 2024 Feb;177:111871. doi: 10.1016/j.ijporl.2024.111871. Epub 2024 Jan 17. PMID: 38266378.

8.  Altamimi AAH, Robinson M, Alenezi EMA, Kuthubutheen J, Veselinović T, Bernabei G, Cayley T, Choi RSM, Brennan-Jones CG. The Impact of Waiting Times on Behavioral Outcomes for Children with Otitis Media: Results from an Urban Ear, Nose, and Throat Telehealth Service. Telemed Rep. 2023 Dec 8;4(1):359-365. doi: 10.1089/tmr.2023.0055. PMID: 38098782; PMCID: PMC10719648.

9.  O'Neil LM, O'Neill M, Whelan F, Leahy T, Wormald R, Ghandour J, Kuthubutheen J. Novel Ear Nose and Throat Live Telehealth and Live Video-otoscopy Clinics in Remote Australia - Outcomes and Comparisons to Traditional Clinic Models. J Laryngol Otol. 2023 Sep 12:1-24. doi: 10.1017/S0022215123001561. Epub ahead of print. PMID: 37698117.

10.  Távora-Vieira D, Marino R, Kuthubutheen J, Broadbent C, Acharya A. Decision making in bone conduction and active middle ear implants - hearing outcomes and experiences over a 10-year period. Cochlear Implants Int. 2023 Oct 17:1-7. doi: 10.1080/14670100.2023.2267900. Epub ahead of print. PMID: 37846847.

11.  Quick ME, Withers S, Plontke SK, Chester-Browne R, Kuthubutheen J. Bilateral intracochlear schwannomas: histopathological confirmation and outcomes following tumour removal and cochlear implantation with lateral wall electrodes. HNO. 2023 Oct 30. English. doi: 10.1007/s00106-023-01379-7. Epub ahead of print. PMID: 37904024

12.  Ng, Jia Hui MBBS, MRCS(Edin), MMed(ORL)*,‡; Bala, Arul MBBS(Hons), FRACS§; Hendriks, Thomas MBBS, MPhil*; Kuthubutheen, Jafri MBBS(Hons), PhD, FRACS*,‖. Improving Surgical Outcomes in Middle Cranial Fossa Cerebrospinal Fluid Leak Repair. Neurosurgery Practice 4(3):e00042, September 2023.

13.  Marino R, Eager K, Kuthubutheen J, Kadhim L, Távora-Vieira D. Results of a Novel, Nonsurgical Bone-Conduction Hearing Aid for the Treatment of Conductive Hearing Loss in Australian Children. Otol Neurotol. 2023 Aug 23.

14.  Távora-Vieira D, Voola M, Kuthubutheen J, Friedland P, Gibson D, Acharya A. Evaluation of the Performance of OTOPLAN-Based Cochlear Implant Electrode Array Selection: A Retrospective Study. J Pers Med. 2023 Aug 20;13(8):1276. doi: 10.3390/jpm13081276. PMID: 37623526; PMCID: PMC10455663.

15.  Braack KJ, Miles T, Amat F, Brown DJ, Atlas MD, Kuthubutheen J, Mulders WHAM, Prêle CM. Using x-ray micro computed tomography to quantify intracochlear fibrosis after cochlear implantation in a Guinea pig model. Heliyon. 2023 Aug 19;9(9):e19343. 

16.  Crohan W, Kuthubutheen J. Middle Ear Osteoma with assimilation of ossicles: An unusual case of conductive hearing loss. Cureus April 2023 (in press)

17.  Ng JH, Bala A, Kuthubutheen J. Improving Surgical Outcomes in Middle Cranial Fossa Cerebrospinal Fluid Leak Repair. Neuroopen April 2023 (in press)

18.  Alenezi EM, Veselinović T, Tao KF, Altamimi AA, Tran TT, Herbert H, Kuthubutheen J, McAullay D, Richmond PC, Eikelboom RH, Brennan-Jones CG. Ear Portal: An urban-based ear, nose, and throat, and audiology referral telehealth portal to improve access to specialist ear-health services for children. J Telemed Telecare. 2023 Mar 14:

19.  Hendriks T, Kirsch C, Gibson D, Kuthubutheen J. Temporal Bone Skull Base Defects-The Value and Importance of Early Based Detection to Prevent Late Costly Morbidity and Mortality. J Neurol Surg B Skull Base. 2022 Nov 12;83(6):653-662. 

20.  Chidambaram R, Hendriks T, Phung S, Kuthubutheen J. Symptoms Underestimate the Presence of Obstructive Sleep Apnea in Patients with Spontaneous Cerebrospinal Fluid Leaks of the Temporal Bone. Otol Neurotol. 2022 Dec 1;43(10):e1194-e1199. 

21.  Ng JH, Kuthubutheen J. Postmastoidectomy Hyperacusis Syndrome: Clinical Features and Treatment. Otol Neurotol. 2022 Oct 1;43(9):e1020-e1023. 

22.  Tay S, Bowen AC, Blyth CC, Clifford P, Clack R, Ford T, Herbert H, Kuthubutheen J, Mascaro F, O'Mahoney A, Rodrigues S, Tran T, Campbell AJ. A quality improvement study: Optimizing pneumococcal vaccination rates in children with cochlear implants. Vaccine. 2022 Jul 30;40(32):4531-4537

23.  Mooranian A, Jones M, Walker D, Ionescu CM, Wagle SR, Kovacevic B, Chester J, Foster T, Johnston E, Kuthubutheen J, Brown D, Atlas MD, Mikov M, Al-Salami H. Pharmacological Dose-Effect Profiles of Various Concentrations of Humanised Primary Bile Acid in Encapsulated Cells. Nanomaterials (Basel). 2022 Feb 15;12(4):6472. 

24.  Reid A, Bowen AC, Brennan-Jones CG, Kuthubutheen JB. Congenital cytomegalovirus: the case for targeted infant screening in Australia. Med J Aust. 2022 Mar 7;216(4):167-171.

25.  Davidson L, Foley DA, Clifford P, Blyth CC, Bowen AC, Hazelton B, Kuthubutheen J, McLeod C, Rodrigues S, Tay SM, Campbell AJ. Infectious complications and optimising infection prevention for children with cochlear implants. J Paediatr Child Health. 2022 Feb 9.

26.  Jones M, Ionescu CM, Walker D, Wagle SR, Kovacevic B, Chester J, Foster T, Johnston E, Kuthubutheen J, Brown D, Atlas MD, Mikov M, Mooranian A, Al-Salami H. Biguanide Pharmaceutical Formulations and the Applications of Bile Acid-Based Nano Delivery in Chronic Medical Conditions. Int J Mol Sci. 2022 Jan 13;23(2):836. 

27.  Mooranian A, Jones M, Ionescu CM, Walker D, Wagle SR, Kovacevic B, Chester J, Foster T, Johnston E, Kuthubutheen J, Brown D, Mikov M, Al-Salami H. Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation. J Funct Biomater. 2021 Nov 30;12(4):68. 

28.  Mooranian A, Ionescu CM, Walker D, Jones M, Wagle SR, Kovacevic B, Chester J, Foster T, Johnston E, Kuthubutheen J, Brown D, Atlas MD, Mikov M, Al-Salami H. Single-Cellular Biological Effects of Cholesterol-Catabolic Bile Acid-Based Nano/Micro Capsules as Anti-Inflammatory Cell Protective Systems. Biomolecules. 2022 Jan 4;12(1):73

29.  Pollaers, K., Bumbak, P., & Kuthubutheen, J. (2021). Outcomes following tympanoplasty surgery using porcine derived small intestinal submucosa (SIS). The Journal of Laryngology & Otology, 1-12. 

30.  Reid A, Firns S, Tao K, Maywood E, Herbert H, Mulders WAM, Kuthubutheen J, Brennan-Jones C. Early detection of hearing loss for infants in Western Australia: Comparison to international benchmarks. J Paediatr Child Health. 2021 Sep 13.

31.  Mooranian A, Foster T, Ionescu CM, Carey L, Walker D, Jones M, Wagle SR, Kovacevic B, Chester J, Johnstone E, Kuthubutheen J, Brown D, Atlas MD, Mikov M, Al-Salami H. The Effects of Primary Unconjugated Bile Acids on Nanoencapsulated Pharmaceutical Formulation of Hydrophilic Drugs: Pharmacological Implications. Drug Des Devel Ther. 2021 Oct 23;15:4423-4434. 

32.  Leedman SR, Kuthubutheen J. Metallic foreign body adjacent to the round window: a rare cause for chronic tympanic membrane perforation with hearing loss. BMJ Case Rep. 2021 May 20;14(5):e240106.

33.  Esmaili A, Withers S, Kuthubutheen J. A retrospective cohort study on false positive diffusion weighted MRI in the detection of cholesteatoma. Australian Journal of Otolaryngology 4, Jun 18 2021 

34.  Hendriks T, Bala A, Kuthubutheen J. Spontaneous cerebrospinal fluid leaks of the temporal bone - clinical features and management outcomes. Auris Nasus Larynx. 2021 Apr 5:S0385-8146(21)00114-0. 

35.  Hendriks T, Thompson A, Boeddinghaus R, Tan HEI, Kuthubutheen J. Radiological findings in spontaneous cerebrospinal fluid leaks of the temporal bone. J Laryngol Otol. 2021 May 10:1-7. 

36.  Yael Friedland, Timothy Whitmore, Eric Chu & Jafri Kuthubutheen (2021) Mycobacterium tuberculosis of the temporal bone, Acta Oto-Laryngologica Case Reports, 6:1, 30-35

37.  Távora-Vieira D, Voola M, Majteles L, Timms L, Acharya A, Kuthubutheen J. Extended scope of practice audiology in the ENT outpatient clinic - a pilot study. Int J Audiol. 2021 Mar 26:1-5. 

38.  Chidlow C, Prunty S, Hinton-Bayre A, Shubhraj S, Renton J, Kuthubutheen J. Practice patterns in myringoplasty surgery among Australian surgeons. Aust J Otolaryngol 2020;3:28. 

39.  Pollaers K, Thompson A, Kuthubutheen J. Cochlear nerve anomalies in paediatric single-sided deafness - prevalence and implications for cochlear implantation strategies. J Laryngol Otol. 2020 Dec 7:1-4. 

40.  Hendriks T, Pollaers K, Phillips T, Kuthubutheen J. Tongue arteriovenous malformation with oral haemorrhage treated by embolisation. BMJ Case Rep. 2020;13(6):e235366. 

41.  Kuthubutheen J, Broadbent C, Marino R, Távora-Vieira D. The Use of a Novel,Nonsurgical Bone Conduction Hearing Aid System for the Treatment of ConductiveHearing Loss. Otol Neurotol. 2020 Apr 10

42.  Zhen E, Kuthubutheen J, Misso D, Rodrigues S, Thompson A. 3 Tesla MRI brain scanning under general anaesthesia in a paediatric 3 Tesla-compatible cochlear implant recipient, first reported case: Clinical considerations and implications for future practice. Int J Pediatr Otorhinolaryngol. 2020 Mar 21;133:110015

43.  Weng W, Reid A, Thompson A, Kuthubutheen J. Evaluating the success of a newly introduced Feed and Wrap protocol in magnetic resonance imaging scanning of the temporal bone for the evaluation of congenital sensorineural hearing loss. Int J Pediatr Otorhinolaryngol. 2020 Jan 29;132:109910

44.  Nateghifard K, Low D, Awofala L, Srikanthan D, Kuthubutheen J, Daly M, Chan H,Irish J, Chen J, Lin V, Le TN. Cone beam CT for perioperative imaging in hearing preservation Cochlear implantation - a human cadaveric study. J Otolaryngol Head Neck Surg. 2019 Nov 21;48(1):65

45.  Withers S, Plontke SK, Boeddinghaus R, Kuthubutheen J, Atlas M. Bilateral intracochlear schwannomas in a patient with no genetic or clinical features of neurofibromatosis type 2. HNO. 2019 Oct 9

46.  Chin O, Dharsono F, Kuthubutheen J, Thompson A. Is CT necessary for imaging paediatric congenital sensorineural hearing loss? Cochlear Implants Int. 2019 Sep 23:1-8

47.  Kuthubutheen J, Grewal A, Symons S, Nedzelski J, Shipp D, Lin V, Chen J. The Effect of Cochlear Size on Cochlear Implantation Outcomes. Biomed Res Int. 2019 Jun 4;2019:5849871.

48.  Hendriks, T., Bala, A., Rodrigues, S., & Kuthubutheen, J. Spontaneous cerebrospinal fluid (CSF) otorrhea in Western Australia—an emerging entity? Australian Journal of Otolaryngology.Australian Journal Of Otolaryngology, 2. doi:10.21037/ajo.2019.01.07

49.  Pollaers K, Kuthubutheen J. Spontaneous Otogenic Pneumocephalus due to Frequent Plane Travelling. Case Rep Otolaryngol. 2019 Mar 19;2019

50.  Pollaers K, Broadbent C, Kuthubutheen J. Misplaced incus: an unusual complication of a temporal bone fracture. BMJ Case Rep. 2019 Mar 20;12(3)

51.  Davis AL, Gangatharan S, Kuthubutheen J. Unusual case of unilateral conductive hearing loss: chronic lymphocytic leukaemia. BMJ Case Rep. 2018 Oct 12;2018

52.  Soumya, Hinton-Bayre A, Coates H, Ooi EH, Kuthubutheen J. Myringoplasty outcomes of Indigenous Australians in the West Kimberley region of Western Australia. Aust J Otolaryngol 2018;1:18.

53.  Esmaili A, Wang AYY, Kuthubutheen J. A Rare Cause of a Fluctuating Cystic Lesion in the External Auditory Canal. Case Rep Otolaryngol. 2018 Jan 23;2018:6197314

54.  Kuthubutheen J, Joglekar S, Smith L, Friesen L, Smilsky K, Millman T, Ng A, Shipp D, Coates H, Arnoldner C, Nedzelski J, Chen J, Lin V. The Role of Preoperative Steroids for Hearing Preservation Cochlear Implantation: Results of  a Randomized Controlled Trial. Audiol Neurootol. 2017;22(4-5):292-302

55.  Kuthubutheen J, Smith L, Hwang E, Lin V. Preoperative steroids for hearing preservation cochlear implantation: A review. Cochlear Implants Int. 2016;17(2):63-74

56.  Kuthubutheen J, Lin V, Chen J. Comment on the Paper by Weder et al. Entitled 'Benefit of a Contralateral Routing of Signal Device for Unilateral Cochlear Implant Users'. Audiol Neurootol. 2015 Sep 1;20(5):337-338

57.  Kuthubutheen J, Coates H, Rowsell C, Nedzelski J, Chen JM, Lin V. The role of extended preoperative steroids in hearing preservation cochlear implantation. Hear Res. 2015 Sep;327:257-64

58.  Marino R, Lampacher P, Dittrich G, Tavora-Vieira D, Kuthubutheen J, Rajan GP. Does Coupling and Positioning in Vibroplasty Matter? A Prospective Cohort Study. Otol Neurotol. 2015 Aug;36(7):1223-30

59.  Osborn HA, Kuthubutheen J, Yao C, Chen JM, Lin VY. Predicting Microsurgical Aptitude. Otol Neurotol. 2015 Aug;36(7):1203-8

60.  Park E, Amoodi H, Kuthubutheen J, Chen JM, Nedzelski JM, Lin VY. Predictors of round window accessibility for adult cochlear implantation based on pre-operative CT scan: a prospective observational study. J Otolaryngol Head Neck Surg. 2015 May 28;44:20

61.  Grewal AS, Kuthubutheen J, Smilsky K, Nedzelski JM, Chen JM, Friesen L, Lin VY. The role of a new contralateral routing of signal microphone in established unilateral cochlear implant recipients. Laryngoscope. 2015 Jan;125(1):197-202. doi: 10.1002/lary.24873. 

62.  Kuthubutheen J, Mittmann N, Amoodi H, Qian W, Chen JM. The effect of different utility measures on the cost-effectiveness of bilateral cochlear implantation. Laryngoscope. 2014 Aug 28. 

63.  Arnoldner C, Lin VY, Bresler R, Kaider A, Kuthubutheen J, Shipp D, Chen JM. Quality of Life in Cochlear Implantees: Comparing Utility Values obtained through SF-6D and HUI-3. Laryngoscope. 2014 Feb 18

64.  Van de Heyning P, Adunka O, Arauz SL, Atlas M, Baumgartner WD, Brill S, Bruce I, Buchman C, Caversaccio M, Dillon M, Eikelboom R, Eskilsson G, Gavilan J, Godey, B, Green K, Gstoettner W, Hagen R, Han D, Iwasaki S, Kameswaran M, Karltorp E, Kleine Punte A, Kompis M, Kuthubutheen J, Kuzovkov V, Lassaletta L, Li Y, Lorens A, Manikoth M, Martin J, Mlynski R, Mueller J, O'Driscoll M, Parnes L, Pillsbury H, Prentiss S, Pulibalathingal S, Raine CH, Rajan G, Rajeswaran R, Riechelmann H, Rivas A, Rivas JA, Senn P, Skarzynski PH, Sprinzl G, Staecker H, Stephan K, Sugarova S, Usami SI, Wolf-Magele A, Yanov Y, Zernotti ME, Zimmerman K, Zorowka P, Skarzynski H. Standards of practice in the field of hearing implants. Cochlear Implants Int. 2013 Jun;14 Suppl 2:1-5.

65.  Carraro M, Negandhi J, Kuthubutheen J, Propst EJ, Kus L, Lin VY, Harrison RV. Attenuating Cardiac Pulsations within the Cochlea: Structure and Function of Tortuous Vessels Feeding Stria Vascularis. ISRN Otolaryngol. 2013 May 19; 2013:

66.  Távora-Vieira D, Marino R, Krishnaswamy J, Kuthubutheen J, Rajan GP. Cochlear implantation for unilateral deafness with and without tinnitus: a case series. Laryngoscope. 2013 May;123(5):1251-5 Epub 2013 Apr 2.

67.  Ganhewa AD, Kuthubutheen J. A diagnostic dilemma of central skull base osteomyelitis mimicking neoplasia in a diabetic patient. BMJ Case Rep. 2013 Jan 25;2013.

68.  Helbig S, Rajan GP, Stöver T, Lockley M, Kuthubutheen J, Green KM. Hearing preservation after cochlear reimplantation. Otol Neurotol. 2013 Jan;34(1):61-5.

69.  Rajan GP, Kontorinis G, Kuthubutheen J. The Effects of Insertion Speed on Inner Ear Function during Cochlear Implantation: A Comparison Study. Audiol Neurootol. 2012 Sep 22;18(1):17-22.

70.  Kuthubutheen J, Hedne CN, Krishnaswamy J, Rajan GP. A case series of paediatric hearing preservation cochlear implantation: a new treatment modality for children with drug- induced or congenital partial deafness.

Audiol Neurootol. 2012;17(5):321-30

71.  Jayawardena J, Kuthubutheen J, Rajan G. Hearing preservation and hearing improvement after reimplantation of pediatric and adult patients with partial deafness: a retrospective case series review. Otol Neurotol. 2012 Jul;33(5):740-4.

72.  Rajan GP, Kuthubutheen J, Hedne N, Krishnaswamy J. The role of preoperative, intratympanic glucocorticoids for hearing preservation in cochlear implantation: a prospective clinical study. Laryngoscope. 2012 Jan; 122(1):190-5.

73.  Leahy TW, Kuthubutheen J. Ingested bony foreign body abutting thoracic aorta. BMJ Case Reports 2011;10.1136

74.  Rajan GP, Lampacher P, Ambett R, Dittrich G, Kuthubutheen J, Wood B, McArthur A, Marino R. Impact of floating mass transducer coupling and positioning in round window vibroplasty. Otol Neurotol. 2011 Feb;32(2):271-7.

75.  Levin B, Kuthubutheen J, Fisher P. Penetrating facial injury. A fortunate functional outcome. Otolaryngol Head Neck Surg. 2010 Mar;142(3 Suppl 1):S36-84.

76.  Rajan GP, Ambett R, Wun L, Dhepnorrarat RC, Kuthubutheen J, Chow Z, Wood B. Preliminary outcomes of cholesteatoma screening in children using non-echo-planar diffusion weighted magnetic resonance imaging. Int J Pediatr Otorhinolaryngol. 2010 Mar;74(3):297-

301. Epub 2010 Jan 15.

77.  Rea S, Kuthubutheen J, Fowler B, Wood F. Burn first aid in Western Australia - do healthcare workers have the knowledge? Burns. 2005 Dec; 31 (8):1029-34